219 A retrospective chart review of outcomes after hyperbaric oxygen therapy for the treatment of calciphylaxis

Calciphylaxis is a rare thrombotic vasculopathy characterized by high mortality with worse outcomes in nephrogenic(NC) compared to non-nephrogenic(NNC) calciphylaxis. Hyperbaric oxygen therapy(HBOT) may be used the treatment of calciphylaxis, however, studies analyzing effectiveness HBOT for calciphylaxis are lacking. This study involved retrospective medical record review 185 adult patients diagnosed between 1/1/2006-12/31/21. For each patient, main lesion, defined as largest or most documented was longitudinally scored based on dermatologist assessment from chart and photographs. All-cause analyzed traditional survival analyses Cox proportional hazard models. Longitudinal wound were mixed effects modeling. 145(78.4%) received standard care 40(21.6%) HBOT, which 14(35.0%) Full HBOT(at least 25 sessions) 26(65.0%) Partial HBOT(less than sessions). associated significantly longer time other treatments(Hazard Ratio 0.221,p=0.0111). 21% 59% care(p=0.0208). Both demonstrated significant improvement healing over time(p=0.001), doing better after end HBOT(p=0.0063). These findings suggest role benefits both healing.